A meta-analysis evaluating the efficacy of Garcinia extract to reduce body weight of overweight or obese.
An English meta-analysis of Onakpoya and colleagues published in the Journal of Obesity in 2011 assessed on the basis of 12 clinical trials, the efficacy of Garcinia on reducing body weight of adults overweight or obese. The meta-analysis showed a modest effect of Garcinia on weight loss compared to placebo.
The Study Rationale
The prevalence of overweight and obesity has increased dramatically in some of the world during the last decade. Many dietary supplements are marketed to supposedly to lose weight but do not make the object of serious studies.
Garcinia extract containing hydroxycitric acid (HCA) integrated into a food supplement could have slimming virtues. HCA is used alone or in combination with other previews. The properties of the HCA would increase the release or availability of serotonin in the brain which cause a decrease in appetite. A reduction in carbohydrate metabolism would also work by inhibiting pancreatic alpha-amylase and alpha glucosidase intestinal.
A dietary supplement containing extract of Garcinia may promote weight loss in overweight or obese.
A dietary supplement containing extract of Garcinia allows it to reduce the body weight of adults overweight or obese?
The English meta-analysis of Onakpoya and colleagues chose 12 clinical trials. These randomized trials were conducted in a double blind placebo face. Participants recruited were to be overweight or obese.
The primary endpoint of the study was to be the change in body weight of the participants between the beginning and end of the intervention.
The Non-Pharmacological Intervention (NPI) assessed
The dietary supplement containing extract of Garcinia was reduced body weight. Based on studies, HCA was administered as capsules, tablets or powder to dissolve in water. The dosage was 1 gram per day to 2.8 grams. The duration of the procedure was 2 to 12 weeks.
The results of this meta-analysis show a marginal change in body weight in favor of the group receiving the food supplement containing extract of Garcinia compared to placebo.
The magnitude of effect across studies is too small to provide clinical evidence that a dietary supplement containing extract of Garcinia promotes weight loss in adults who are overweight or obese.
What it means for Patients
The extract of Garcinia consumed daily for 2 to 12 weeks as a dietary supplement appears to slightly reduce the weight of short-term overweight or obese. But this result should be checked by future more robust studies.
What it means for Healthcare and Prevention Professionals
The extract of Garcinia consumed daily for 2 to 12 weeks as a supplement seems to generate a modest weight loss in the short term for people who are overweight or obese. But its long-term effectiveness remains to be proven.
What it means for Researchers
This meta-analysis synthesizing interventional studies testing the efficacy of a dietary supplement containing extract of Garcinia on weight loss indicates a small positive effect compared to placebo. The overall result should be interpreted with caution because of the heterogeneity of randomized controlled trials identified. Indeed, the number of participants ranged from 11 to 135, the procedure time ranged from 2 to 12 weeks and the dosage of HCA ranged from 1 g to 2.8 g depending on the study. Future clinical trials will have to be more rigorous in developing their protocol.
What it means for Policymakers
The extract of Garcinia favors short-term weight loss in adults who are overweight or obese. But the effect is modest which makes the uncertain clinical significance. Future studies will have to be more rigorous in describing more clearly the duration of the intervention, the daily dose of food supplement and the target population.
Onakpoya I, Hung SK, Perry R, Wider B, Ernst E (2011). The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: A systematic review and meta-analysis of randomised clinical trials. Journal of Obesity, 11, 1-9.
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To reference this Blog en Sante © article.
Ninot G (2015). Efficacy of dietary supplement based on Garcinia on weight loss. Blog en Sante, A63.
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